We all know STING for anti-viral and anti-bacterial reaction is very important, but as of now we do not know STING function in human tumors, this study reveals, we STING signal at times be of colorectal cancer and other cancers in the suppression of state, and this event might promote cell transformation and thus evade the immune surveillance system.
Of colorectal cancer in the United States will affect the health of about 120 million people each year, and every year 150,000 people are diagnosed with colorectal cancer, but this cancer is the third most common cancer in men and women, most of colon cancer will occur in benign polyps form, if early diagnosis, then you can successfully treat, but if the tumor from spreading, it will dramatically decrease the survival rate.
Use of colorectal cancer animal disease model studies, the researchers found, missing STING signal may negatively affect the body's ability to recognize DNA damage in cells, in particular the special cytokines - cell signal is very important for small proteins, can promote tissue damage repair, and start the anti-tumor effect of the immune system is not enough to produce a sufficient immune response to clear the colorectal cancer cells. The researchers said, we found the damaged STING signal can promote damage cells evade immune surveillance system, and if the body is not able to recognize and attack the cancer cells, then the cancer cell proliferation will eventually spread to other parts of the body.
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