Product name:Nodakenin
CAS: 495-31-8
Molecular Formula: Nodakenin
Molecular Weight: 408.3992
Product description:Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance test and the Y-maze test (P<0.05), and also reduced escape latency during training in the Morris water maze test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.
Nodakenin
Send Enquiry Online
This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.For more information OR other products. Please contact us by Email, Tel, Fax or Send online enquiry. We will reply you as soon as possible.
1. Email: sales@chemicalspharm.com
2. Tel: +86 592 5365887