Product name:Vorinostat
CAS:149647-78-9
Molecular Formula:C21H25N3O4
Formula Weight:383.44g/mol
Description:Vorinostat, a second generation polar-planar compound, binds to the catalytic domain of the histone deacetylases (HDACs).It is a member of a larger class of compounds that inhibit histone deacetylases (HDAC).Including vorinostat in treatment of advanced non-small-cell lung cancer (NSCLC) showed improved response rates and increased median progression free survival and overall survival (although the survival improvements were not significant at the P=0.05 level).